Potentiating immune checkpoint blockade therapeutic efficacy using a small molecule activator of integrin cell adhesion receptors

Discover how the small molecule integrin activator 7HP349 enhances immune checkpoint blockade therapy by promoting T cell infiltration into tumors. Learn about its role in boosting anti-CTLA-4 and anti-PD-L1 efficacy in melanoma and colon cancer models.

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Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory

Discover how ICAM-1 expression on dendritic cells regulates CD8+ T cell priming, immune memory formation, and cytotoxic T lymphocyte activation. Learn about the role of long-lasting DC-T cell interactions in effective immune responses.

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Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma

Explore how Vascular Adhesion Protein-1 (VAP-1) and ICAM-1 facilitate T cell adhesion to tumor endothelium in hepatocellular carcinoma (HCC). Learn about their role in tumor immune infiltration and potential implications for cancer immunotherapy.

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Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation

Explore how Alpha 4 Beta 1 (CD49d/CD29) integrin enhances T cell costimulation, driving cytokine induction and transcription factor activation. Learn about its role in immune cell signaling and response modulation.

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