News and Publications
Publication Categories
The importance of prolonged binding to antigen-presenting cells for T cell fate decisions
Discover the crucial role of prolonged T cell interactions with antigen-presenting cells (APCs) in immune response regulation. Learn how ICAM-1 and LFA-1 signaling influence T cell activation, memory formation, and immune system efficiency.
Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
Discover how ICAM-1 expression on dendritic cells regulates CD8+ T cell priming, immune memory formation, and cytotoxic T lymphocyte activation. Learn about the role of long-lasting DC-T cell interactions in effective immune responses.
Regulation of human T lymphocyte coactivation with an alpha4 integrin antagonist peptide
Discover how the cyclic hexapeptide CWLDVC (TBC 772) acts as an alpha4 integrin antagonist, effectively inhibiting human T lymphocyte coactivation and immune cell adhesion. Learn about its potential in targeted immune therapies.
Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation
Explore how Alpha 4 Beta 1 (CD49d/CD29) integrin enhances T cell costimulation, driving cytokine induction and transcription factor activation. Learn about its role in immune cell signaling and response modulation.