Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
Author & Article Information
Authors: Alix Scholer; Stéphanie Hugues; Alexandre Boissonnas; Luc Fetler (luc.fetler@curie.fr); Sebastian Amigorena (sebastian.amigorena@curie.fr)
Affiliations & Notes:
Institut Curie, Centre de Recherche, Paris, F-75248, France
Institut National de la Santé et de la Recherche Médicale U653, Immunité et Cancer, Paris, F-75248, France
Centre National de la Recherche Scientifique, Unité Mixte de Recherche 168, Laboratoire Physico-Chimie Curie, Paris, F-75248, France
These authors contributed equally to this work.
Publication History: Received August 3, 2007; Revised November 19, 2007; Accepted December 18, 2007
DOI: 10.1016/j.immuni.2007.12.016Also available on ScienceDirect
Copyright: © 2008 Elsevier Inc. Published by Elsevier Inc.
Source | J Immunol (1997) 158 (9): 4180–4186. https://doi.org/10.4049/jimmunol.158.9.4180
Summary
The initiation of cytotoxic immune responses requires the direct interaction between naive CD8+ T lymphocytes and dendritic cells (DCs). Multiphoton imaging in intact lymph nodes (LNs) showed that during priming, naive T cells and DCs establish sequentially brief (i.e., minutes) and long (hours) antigen-specific contacts. We show here that the expression of the Intercellular Adhesion Molecule-1 (ICAM-1) by mature DCs is critical for long-lasting contacts with CD8+ T cells but dispensable for short-lived antigen-specific interactions. Serial brief DC-T cell contacts induced early CD8+ T cell activation, proliferation, and differentiation into effector cytotoxic T lymphocytes in the first few days after immunization. ICAM-1-deficient mature DCs, however, failed to induce fully effective priming, because CD8+ T cells produced reduced amounts of interferon γ and were clonally depleted after 2 weeks. In addition, Icam1−/− mice failed to respond to rechallenge. We conclude that ICAM-1-dependent long-lasting interactions between mature DCs and naive CD8+ T cells determine the survival of activated CD8+ T cells and the establishment of effective memory.
See the original article here | Cell Press Immunity