The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

Author & Article Information


Summary

How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8+ T cells encountering “nonsticky” antigen-presenting cells lacking intercellular adhesion molecule-1.


See the original article here | Cell Press Immunity

Previous
Previous

Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes

Next
Next

Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory