The importance of prolonged binding to antigen-presenting cells for T cell fate decisions
Author & Article Information
Authors: John J. Engelhardt ; Matthew F. Krummel (matthew.krummel@ucsf.edu)
Affiliations & Notes:
Department of Pathology, University of California, San Francisco, CA 94143-0511, USA
DOI: 10.1016/j.immuni.2008.01.006Also available on ScienceDirect
Copyright: © 2008 Elsevier Inc. Published by Elsevier Inc.
Summary
How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8+ T cells encountering “nonsticky” antigen-presenting cells lacking intercellular adhesion molecule-1.
See the original article here | Cell Press Immunity