The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

Author & Article Information

• Authors: John J. Engelhardt ; Matthew F. Krummel (matthew.krummel@ucsf.edu)

• Affiliations & Notes:

  • Department of Pathology, University of California, San Francisco, CA 94143-0511, USA

• DOI: 10.1016/j.immuni.2008.01.006Also available on ScienceDirect

• Copyright: © 2008 Elsevier Inc. Published by Elsevier Inc.

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Summary

How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8+ T cells encountering “nonsticky” antigen-presenting cells lacking intercellular adhesion molecule-1.

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See the original article here | Cell Press Immunity