The parallel lives of angiogenesis and immunosuppression: cancer and other tales
Author & Article Information
Authors: Gregory T. Motz & George Coukos
Published: 23 September 2011
DOI: https://doi.org/10.1038/nri3064
Abstract
Emerging evidence indicates that angiogenesis and immunosuppression frequently occur simultaneously in response to diverse stimuli. Here, we describe a fundamental biological programme that involves the activation of both angiogenesis and immunosuppressive responses, often through the same cell types or soluble factors. We suggest that the initiation of these responses is part of a physiological and homeostatic tissue repair programme, which can be co-opted in pathological states, notably by tumours. This view can help to devise new cancer therapies and may have implications for aseptic tissue injury, pathogen-mediated tissue destruction, chronic inflammation and even reproduction.
See the original article here | Nature Review Immunology