Publications
Learn more about our target integrins, our first-in-class molecules, and our novel mechanism of action: Selective Allosteric Integrin Agonism (SAIA)
7 Hills Integrin Activators
LFA-1 activation enriches tumor-specific T cells in a cold tumor model and synergizes with CTLA-4 blockade
Published in: The Journal of Clinical Investigation (May 2022) Authors: Hickman et al.
Use of a small molecule integrin activator as a systemically administered vaccine adjuvant in controlling Chagas disease
Published in: npj Vaccines (September 2021) Authors: Lokugamage et al.
Immune activators – enhancing cell adhesion to safely improve effectiveness of vaccines & cancer immunotherapies
Published in: Drug Development & Delivery (March 2021) Authors: Siddhartha De, Peter Vanderslice
Small molecule agonist of very late antigen-4 (VLA-4) integrin induces progenitor cell adhesion
Published in: Journal of Biological Chemistry (July 2013) Authors: Vanderslice et al.
Poster Presentation Abstracts
Integrin-mediated augmentation of antigenic immunity
Proceedings: The Society for Immunotherapy of Cancer's (SITC) 34th Annual Meeting (2019)
Potentiating immune checkpoint blockade therapeutic efficacy using a small molecule activator of integrin cell adhesion receptors
Proceedings: American Association for Cancer Research (AACR) Annual Meeting 2019
Role of Integrins in Tumor Immune Surveillance
Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy
Published in: Nature Medicine (January 2008)
Authors: Buckanovich et al.
Tumor blood vessels, a difficult hurdle for infiltrating leukocytes
Published in: Biochimica et Biophysica Acta (BBA) - Reviews on Cancer (December 2007)
Authors: Karolien Castermans, Arjan W. Griffioen
Endothelial intercellular adhesion molecule-1 expression is suppressed in human malignancies: the role of angiogenic factors
Published in: Cancer Research (March 1996)
Authors: Karolien Castermans, Arjan W. Griffioen
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy
Published in: Cancer Discovery (May 2014)
Authors: Melero et al.
Cell adhesion molecules and their roles and regulation in the immune and tumor microenvironment
Published in: Frontiers in Immunology (May 2019)
Authors: Harjunpää et al.
Agonist anti-CD137 mAb act on tumor endothelial cells to enhance recruitment of activated T lymphocytes
Published in: Cancer Research (February 2011)
Authors: Palazón et al.
The parallel lives of angiogenesis and immunosuppression: cancer and other tales
Published in: Nature Reviews Immunology (September 2011)
Authors: Gregory T. Motz, George Coukos
Cancer vaccines: trafficking of tumor-specific T cells to tumor after therapeutic vaccination
Published in: The International Journal of Biochemistry & Cell Biology (August 2014)
Authors: Yared Hailemichael, Willem W. Overwijk
Vascular adhesion protein-1 and ICAM-1 support the adhesion of tumor-infiltrating lymphocytes to tumor endothelium in human hepatocellular carcinoma
Published in: The Journal of Immunology (April 1998)
Authors: Yoong et al.
Role of Integrins in T Cell Activation
The importance of prolonged binding to antigen-presenting cells for T cell fate decisions
Published in: Immunity (February 2008)
Authors: John J. Engelhardt, Matthew F. Krummel
Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory
Published in: Immunity (February 2008)
Authors: Scholer et al.
Alpha 4 beta 1 (CD49d/CD29) integrin costimulation of human T cells enhances transcription factor and cytokine induction in the absence of altered sensitivity to anti-CD3 stimulation
Published in: The Journal of Immunology (September 1996)
Authors: T. Udagawa, D. G. Woodside, B. W. McIntyre
Regulation of human T lymphocyte coactivation with an alpha4 integrin antagonist peptide
Published in: The Journal of Immunology (May 1997)
Authors: McIntyre et al.