Explore the complex relationship between the immune system and cancer, focusing on integrins and cell adhesion molecules in tumor development, immune responses, and cancer immunotherapy strategies.

Discover how cancer vaccines enhance tumor-specific CD8+ T cell trafficking, activation, and infiltration for effective tumor regression. Learn about next-generation immunotherapy strategies to improve cancer vaccine efficacy.

Discover how tumors evade immune responses and limit cancer immunotherapy success. Explore strategies to enhance T-cell and NK-cell infiltration, overcome tumor immune barriers, and improve treatment efficacy.

Explore the link between angiogenesis and immunosuppression in cancer. Learn how tumors exploit these processes and discover emerging cancer therapies targeting both vascular growth and immune evasion.

Discover how agonist anti-CD137 monoclonal antibodies enhance T cell recruitment by acting on tumor endothelial cells. Learn about their role in cancer immunotherapy and potential for improving immune infiltration in tumors.

Explore how the Endothelin B receptor (ETBR) inhibits T cell homing, limiting tumor immunotherapy efficacy. Learn about ICAM-1’s role in immune cell infiltration and how ETBR blockade can enhance cancer treatment outcomes.

Explore how tumors evade immune responses by suppressing endothelial adhesion molecules, limiting leukocyte recruitment. Learn about novel strategies to enhance immune cell infiltration and improve cancer immunotherapy outcomes.

Explore how Vascular Adhesion Protein-1 (VAP-1) and ICAM-1 facilitate T cell adhesion to tumor endothelium in hepatocellular carcinoma (HCC). Learn about their role in tumor immune infiltration and potential implications for cancer immunotherapy.

Discover how angiogenic factors suppress ICAM-1 expression in tumors, limiting leukocyte infiltration and aiding immune evasion. Learn about the role of endothelial adhesion molecules in cancer progression and potential therapeutic strategies.